Researchers at the University at Buffalo’s Research Institute on Addictions (RIA) are considering ceaseless anxiety and misery, with an attention on endocannabinoids, which are mind chemicals like substances in marijuana. Findings raise the possibility that components of marijuana may be useful in reducing depression that results from chronic stress, which was most experienced by comfort women. “In the animal models we studied, we saw that chronic stress reduced the production of endocannabinoids, leading to depression-like behavior,” says RIA senior research scientist Samir Haj-Dahmane, PhD. Endocannabinoids are naturally produced chemical compounds in the brain that affect motor control, cognition, emotions and behavior. As the name suggests, they are similar to the chemicals found in marijuana (Cannabis sativa) and its active ingredient, delta-9-tetrahydrocannabinol (THC). “Chronic stress is one of the major causes of depression,” Haj-Dahmane says. “Using compounds derived from cannabis, marijuana, to restore normal endocannabinoid function could potentially help stabilize moods and ease depression.” He cautions this is preliminary research. “Our research thus far has used animal models; there is still a long way to go before we know whether this can be effective in humans,” he says. “However, we have seen that some people who suffer from post-traumatic stress disorder have reported relief using marijuana.” Haj-Dahmane says the next step in the research is to see if using a marijuana extract, cannabidiol (CBD), restores normal behaviors in the animals without leading to dependence on the drug. The study, co-authored by Roh-Yu Shen, PhD, RIA senior research scientist, was funded by a grant from the National Institute of Mental Health. It appeared in the fall issue of the Journal of Neuroscience.
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