Marijuana for Depression

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Researchers at the University at Buffalo’s Research Institute on Addictions (RIA) are considering ceaseless anxiety and misery, with an attention on endocannabinoids, which are mind chemicals like substances in marijuana. Findings raise the possibility that components of marijuana may be useful in reducing depression that results from chronic stress, which was most experienced by comfort women“In the animal models we studied, we saw that chronic stress reduced the production of endocannabinoids, leading to depression-like behavior,” says RIA senior research scientist Samir Haj-Dahmane, PhD. Endocannabinoids are naturally produced chemical compounds in the brain that affect motor control, cognition, emotions and behavior. As the name suggests, they are similar to the chemicals found in marijuana (Cannabis sativa) and its active ingredient, delta-9-tetrahydrocannabinol (THC). “Chronic stress is one of the major causes of depression,” Haj-Dahmane says. “Using compounds derived from cannabis, marijuana, to restore normal endocannabinoid function could potentially help stabilize moods and ease depression.” He cautions this is preliminary research. “Our research thus far has used animal models; there is still a long way to go before we know whether this can be effective in humans,” he says. “However, we have seen that some people who suffer from post-traumatic stress disorder have reported relief using marijuana.” Haj-Dahmane says the next step in the research is to see if using a marijuana extract, cannabidiol (CBD), restores normal behaviors in the animals without leading to dependence on the drug. The study, co-authored by Roh-Yu Shen, PhD, RIA senior research scientist, was funded by a grant from the National Institute of Mental Health. It appeared in the fall issue of the Journal of Neuroscience.

Person experiencing chronic stress

 

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Preservation of Breast Biopsy Specimens

Dr. Pat Whitworth

In place Medical Corporation won FDA 510(k) leeway for its Intact extraction framework to be utilized to safeguard evacuated breast tissue of up to 30mm in breadth. Once the territory is arranged, the wand is embedded through a 6mm-8mm cut and the tip grows to encompass the tissue. A 10 second blast of radiofrequency vitality is conveyed through the tip removing the tissue around the example and liberating it for simple evacuation. The specimen keeps up its building design and is prepared for standard histologic assessment. The gadget accompanies four distinctive bushel sizes that wrap around the example, while the same wand is utilized with every one of the four. Dr. Pat Whitworth, Director, Nashville Breast Center, noted, “This new FDA clearance is highly significant, not just for Intact Medical, but more importantly, for women’s health professionals and patients, globally.  The expanded clearance recognizes the unique features and significant advantages of the Intact technology compared to core needle biopsy and open surgical excision procedures in certain situations. Specifically, for small breast lesions up to 30mm in diameter, the ability of the Intact system to remove and preserve the entire lesion architecture for assessment by the pathologist combines the minimally-invasive benefits of core biopsy with the diagnostic assurances of traditional surgical excisional biopsy. As someone who has performed more than 1,000 procedures with the Intact, I can attest to the advantages of this option for my patients.” John Vacha, President and Chief Executive Officer of Intact Medical, noted, “This FDA clearance represents an important milestone for the company and is an acknowledgement of the unique capabilities of the Intact technology.

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Lab-Grown Vagina

Tube in lab

Lab-grown fully functional vaginas

Following the time when researchers developed a human bladder in a lab in 1996, analysts have kept on developing more unpredictable organs. Beating human hearts have additionally been become in the lab and infected with ailment to test different medications.As a result of these medical advancements, people have had their lives changed for the better. One of the most recent successful lab grown organ transplants is the female vagina. Researchers were able to successfully implant lab-grown vaginas into 4 teenage girls, and the results were published earlier this year. Tissue samples from the poorly developed vulva as well as a biodegradable scaffold were used.  a“We were able to shape the scaffold specifically for each patient, and place this device with the cells in a bio-reactor – which is an oven-like device and has the same conditions as the human body – for about a week, until it was slightly more mature.”– Dr. Anthony Atala, lead researcher, director of Wake Forest Baptist Medical Centre’s Institute for regenerative medicine. They grew each vagina from the cells of each patient and then implanted them. So far so good, as the patients are now able to be sexually active and have reported normal functioning. All of the women reported normal  levels of “desire, arousal, lubrication, orgasm and satisfaction.”

Dr. Anthony Atala

The vaginas were constructed at the Wake Forest Baptist Medical Centre in North Carolina. Dr. Anthony Atala said that  it is really for the first time we’ve created a whole organ that was never there to start with, it was a challenge. A functioning vagina was a very important thing for these women’s lives and witnessing the difference it made to them was very rewarding to see.” So for those women, even you are Asian teacher, manager, assistant, US comfort women, Indian nurses, or whatever race you are and job you have, and having problem with your vagina, you might want to consider this new medical breakthrough.

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New Lens-Free Microscope

Tissue Image created by the new free microscope

The lab of Dr. Aydogan Ozcan at UCLA appears like a continually streaming wellspring of new optical devices that can be utilized as a part of biomedical applications. Recently we wrote about another fluorescence imaging cell phone connection created by Ozcan et. al. that can be utilized to spot and measure DNA strands, and in the past we’ve secured different advances the group created to number cells, holographic transforming to break down them, and high-res 3d imaging of examples on a minor chip. Today we learn of another study distributed by the analysts in Science Translational Medicine depicting another without lens microscopy method that takes into account wide-field survey of pathology slides utilizing a little, shabby, and versatile gadget. The gadget makes a holographically reproduced picture the items inside which can be brought into center at any profundity taking after the picture catch. Not at all like ordinary optical magnifying instruments, this does not require any mechanical parts to move the lens, making picture catch almost programmed. From the study abstract in Science Translational Medicine, using this lens-free on-chip microscope, we successfully imaged invasive carcinoma cells within human breast sections, Papanicolaou smears revealing a high-grade squamous intraepithelial lesion, and sickle cell anemia blood smears over a FOV of 20.5 mm2. The resulting wide-field lens-free images had sufficient image resolution and contrast for clinical evaluation, as demonstrated by a pathologist’s blinded diagnosis of breast cancer tissue samples, achieving an overall accuracy of ~99%. By providing high-resolution images of large-area pathology samples with 3D digital focus adjustment, lens-free on-chip microscopy can be useful in resource-limited and point-of-care settings.

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Synthetic Platelets to Heal Wounds

Synthetic Platelet

Basic wound recuperating has been progressed with an engineered platelet that gathers at destinations of harm, clusters and quits draining three times speedier. The engineered platelets have reasonable size, plate shape, adaptability, and the same surface proteins as genuine platelets. Fake platelets made by the University of California and Case Western Reserve University have been indicated to stop draining in mouse explores much speedier than nature can all alone. Shockingly, they have possessed the capacity to integratively emulate the shape, size, adaptability and surface science of true blood platelets on egg whites based molecule stages. The specialists accept these four outline considers together are key for instigating clusters to structure speedier at vascular damage locales while keeping unsafe clumps from framing somewhere else in the body. The new engineering, reported in the diary ACS Nano, is gone for stemming draining in patients experiencing traumatic harm, experiencing surgeries or experiencing coagulating issue platelet deformities or an absence of platelets. Further, it could be utilized to convey medications to target destinations in patients enduring atherosclerosis, thrombosis or other platelet-included pathologic conditions. Anirban Sen Gupta, partner educator of biomedical building at Case Western Reserve, awhile ago composed peptide-based surface sciences that copy the coagulation applicable exercises of true platelets. Expanding on this work, he now concentrates on fusing morphological and mechanical prompts that are regularly display in platelets to further refine their configuration. Morphological and mechanical elements impact the margination of characteristic platelets to the vein divider, and just when they are close to the divider can the discriminating coagulation advancing substance associations occur.

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Battle With A Deadly Instestinal Disease

Catherine Duff underwent fecal transplants to fight a deadly intestinal disease

According to the U.S. Centers for Disease Control and Prevention, each year in the U.S., Clostridium difficile bacteria or C. diff causes 250,000 infections requiring hospitalization, and 14,000 deaths. Catherine Duff, a 58 year old woman who’s suffering from C. diff was in renal failure after the antibiotics that had been given to her to fight the infection and life-threatening diarrhea weren’t working. Antibiotics are frequently fail to treat the infection, it even allows more C. diff bacteria to take hold. The doctors decided to remove her colon, even they weren’t sure if she could survive after the surgery. Duff said that she felt 95 percent better after the surgery.  A fecal transplant uses the healthy bacteria from a normal stool sample. It will reseed a weakened intestine so it ca fight off infections naturally. Transplants have been given via a colonoscopy, which requires daylong prep, anesthesia and an outpatient clinic, but researchers are now working for a newer methods that are less costly, easier and can be done in an office of a physician. An associate professor of medicine and infectious diseases at Harvard Medical School, Elizabeth Hohmann, M.D., has been testing frozen stool sample given through a tube in the nose or during colonoscopy, as well as capsules containing frozen material that are swallowed with water. Both of which have resulted in 90 and 91 percent success rate. she said that the procedure worked on children as young as 2 and adults as old as 90. Some patients are too repulsed to try it and saying that they’d rather die but for Duff, who had C. diff eight times between 2005 and 2012 and underwent two fecal transplants, the experience was transformative.

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A Device for Blood Filtration

Aehtlon Medical’s Hemopurifier

It is nice to know that there are technologies already in existence that may be able to treat infected patients like the device from Aethlon Medical, the Hemopurifier. It is capable of filtering blood of impurities like viruses and exosomes that are related to tumor growth. Hemopurifier is also being used to filter the blood of a Ugandan doctor who contracted Ebola while on a WHO mission in Sierra Leone. It can be used with standard dialysis and continuous renal replacement therapy (CRRT) machines without requiring any special hardware upgrades. According to Aethlon Medical, Hemopurifier is a first-in-class device with broad-spectrum capabilities against viral pathogens, including the human immunodeficiency virus (HIV), hepatitis C virus (HCV) and numerous bioterror and pandemic threats. Studies shows that this device is safe and it provides average viral load reductions of greater than 50% during for-hour treatment periods in both HCV and HIV infected individuals without the administration of antiviral drugs. Studies have also documented that the Hemopurifier captures exosomes underlying cancer, including colorectal, lymphoma, melanoma, ovarian, and breast cancer. Studies were conducted at the Apollo Hospital, Fortis Hospital, Sigma New Life Hospital, and the Medanta Medicity Institute, all located in India and in result, Hemopurifier therapy has been successfully administered in approximately one hundred treatment experiences in health compromised HIV and HCV infected individuals. These In vitro validation studies that demonstrated the ability of the Hemopurifier to capture Zaire and other strains of ebola virus were conducted by researchers at the United States Army Medical Research Institute for Infectious Diseases (USAMRIID) and the United States Centers for Disease Control and Prevention (CDC).

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Surgery

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In medicine, surgery (from the Greek χειρουργική, or chirurgical, and latin chirurgiae meaning “hand work”) is a medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance, or sometimes for some other reason. An act of performing surgery may be called a surgical procedure, operation, or simply surgery. In this context, the verb operating means performing surgery. The adjective surgical means pertaining to surgery; e.g. surgical instruments or surgical nurse. The patient or subject that the surgery is being performed on can be a person or an animal. A surgeon is a person who performs operations on patients. Persons described as surgeons are commonly medical practitioners, but the term is also applied to podiatrists, dentists and veterinarians. Surgery can last from minutes to hours, but is typically not an ongoing or periodic type of treatment. -Source

Modern Surgery Overview

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Although it is sometimes difficult to determine when a medical procedure is considered surgery, a medical treatment that involves a cutting of a patient’s live tissue (e.g., hair and nails are dead tissue) is usually considered surgery of some sort. A medical procedure involving a drilling of live tissue in a body would often be considered surgery, but mere piercing of a body is not necessarily surgery since piercing is often done for taking samples or draining fluids from or injecting materials into the body, or setting up intravenous drip, and usually does not require suturing to close the pierced opening. Even if a medical procedure or treatment does not include cutting or drilling of live tissue in a body, it may be considered surgery, if it involves common surgical procedure or a setting, such as use of an operating room or table in a hospital, anesthesia, antiseptic conditions, typical surgical instruments, and suturing or stapling. Surgery is considered an invasive procedure. Examples of surgery without cutting the body may include debridement or closing (suturing or stapling) an open wound or applying skin grafts if done under typical surgical conditions. Many types of more complicated or involved surgery are obviously considered surgery, since they involve common surgical procedure or setting as mentioned above. A medical procedure may be surgery even if not all of the typical surgical conditions or procedures mentioned above are used. -Source

Highend Drugs Being Abused in the U.S.

Drug trade and abuse remain to be a major issue being faced by the U.S. government. This drug crisis that besets the country affects both adults and teens.

prescription-drug-abuse

A new survey has found a rise in prescription drug abuse among teenagers. Data from the study showed that 24 percent of high school students or equivalent to more than five million have abused certain medications. This figure is up by 33 percent from 2008.

Among the teens who claimed having abused prescription drugs, 20 percent said their first experience was even before they reached the age of 14. In addition, 27 percent said they mistakenly believed that frequently using prescription drugs was safer than using cocaine or ecstasy or the so-called street drugs. [Read more…]