D Free Device, The Bowel Movement Indicator



In the wake of creating the printing press, mastering the force of flight, and uniting the world through the force of the Internet, its motivating to know there is still more human creativity out there enhancing and providing for us groundbreaking items like a USB-controlled rice ball hotter. However our species is a brilliant group and we keep on discovering better approaches to tackle innovation, in the same way as a Japanese startup that has declared another wearable gadget that predicts defecations and gives the client a 10-moment heads-up before expecting to discover a can. It may not be as trendy of a wearable as the upcoming Apple Watch, but it could be a life-changing device for people, especially, Japan comfort women, who suffer from incontinence or those working in the nursing home industry. Triple W, a Japanese startup based in California, recently pitched the D Free device at a venture capital event. The wearable was presented as a way to help out anyone who has less-than-predictable bowels as a way to give them ample time to find a toilet. D Free could be particularly useful for people in wheelchairs or with limited mobility, giving them ample time to make it to the bathroom. Especially for assisted living facilities or nursing homes, the device could be a game changer, making it easier on attendants who have a heads-up about when to help their patients to avoid an accident. To use D Free, you attach the device to your stomach and connect it to an app on your smartphone. The sensors in the device then detect any movement or swelling in your intestines and sends a notification to your smartphone that in about 10 minutes, it’s going to best if you’re near a toilet. The app then records your bowel movements throughout the day to learn your daily habits and give you more accurate notifications in the future.

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D free app


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Spot Early Autism and Help Identify Genes Responsible

3D Face Scan

Autism is a spectrum of closely related disorders diagnosed in patients who exhibit a shared core of symptoms, including delays in learning to communicate and interact socially. Early detection of autism in children is the key for treatments to be most effective and produce the best outcomes. Using advanced three-dimensional imaging and statistical analysis techniques, researchers at the University of Missouri have identified facial measurements in children with autism that may lead to a screening tool for young children and provide clues to its genetic causes. Expanding upon previous studies using two-dimensional imaging, Duan, working with Judith Miles, professor emerita of child health-genetics in the MU Thompson Center for Autism and Neurodevelopmental Disorders, used a system of cameras to photograph and generate three-dimensional images of children’s faces. The children selected were between 8 and 12 years old. One group of children had been diagnosed with autism by the Thompson Center; the other group consisted of typically developing children. Researchers photographed the faces of children using three-dimensional imaging, which allowed scientists to measure distances along the curvature of the face rather than in a straight line as had been done in previous tests. Duan then ran sophisticated statistical analyses to measure minute differences in the facial measurements of each group. The group’s analyses revealed three distinct subgroups of children with autism who had similar measurement patterns in their facial features. These subgroups also shared similarities in the type and severity of their autism symptoms.

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World’s Smallest Pediatric Heart Valve

Heart Valve

St. Jude Medical got an investigational device exemption (IDE) from the FDA and is dispatching a U.S. trial of the Masters HP Series 15 mm pediatric heart valve. The gadget is the littlest mechanical heart valve on the planet and will be tried if all else fails alternative for little youngsters requiring a mitral valve substitution. Since the smallest valves available are 16 mm in diameter, patients with smaller anatomies often receive replacement valves larger than what would be optimally appropriate. Too frequently this leads to misconfigured placement, inappropriate blood flow, tissue damage, and other side effects. Some details about what led to the development of the new valve. In 2007, the U.S. Congress passed the Pediatric Medical Device Safety and Improvement Act to prompt development of medical devices designed and engineered specifically for the pediatric patient population. With its legacy of innovation in the field of pediatric cardiology, St. Jude Medical was uniquely positioned to meet the challenge of designing a mechanical heart valve that could provide very young patients a chance of survival until they can be implanted with a larger, permanent valve implant they will carry with them the rest of their life. The launch of the HALO IDE stems from a new approach to the design, evaluation and regulatory approval of pediatric heart valves that emerged from an FDA led workshop in 2010 organized in response to the pressing need to develop products for this patient population. In a speech held in October 2014 the St. Jude Medical pediatric heart valve was cited by FDA Commissioner Margaret A. Hamburg, M.D., as an example of what collaboration can achieve when industry, FDA staff, clinicians and academics come together to support pediatric medical device development.

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For A Child Born Without A Hearing Nerve

Auditory Brainstem Implants

A multi-institutional group of hearing to and communication specialists drove by the Keck School of Medicine of USC is breaking supersonic limits for kids conceived without a listening to nerve in a clinical trial upheld by the National Institutes of Health. Hearing to misfortune shows in different structures, the vast majority of which can be halfway restored through  hearing aids and cochlear implants. Those devices cannot help a small population of individuals who do not have a cochlear, or hearing, nerve, these people are unable to perceive sound, no matter how loud, outside of feeling vibration. The ABI is considered revolutionary because it stimulates neurons directly at the human brainstem, bypassing the inner ear entirely. Surgeons outside the United States have been doing ABI surgeries in children for more than 10 years, but there was never a formal safety or feasibility study under regulatory oversight. In the United States, the ABI is approved for use only in patients 12 years or older with neurofibromatosis type II, an inherited disease that causes a non-malignant brain tumor on the hearing nerve, but it has shown limited effectiveness in adults. Scientists believe that the ABI would be more effective in younger children, when their brains are more adaptable. The clinical trial will attempt to prove that the surgery is safe in young children and allow researchers to study how the brain develops over time and how it learns to hear sound and develop speech.  “Hearing loss can be devastating to a child’s social development, and for some children, the ABI is their last viable chance to hear,” said Keck School of Medicine Professor Robert Shannon, an investigator for the trial and a leading scientist in the development of ABI technology since 1989.

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Marijuana for Depression

Picture of marijuana


Researchers at the University at Buffalo’s Research Institute on Addictions (RIA) are considering ceaseless anxiety and misery, with an attention on endocannabinoids, which are mind chemicals like substances in marijuana. Findings raise the possibility that components of marijuana may be useful in reducing depression that results from chronic stress, which was most experienced by comfort women“In the animal models we studied, we saw that chronic stress reduced the production of endocannabinoids, leading to depression-like behavior,” says RIA senior research scientist Samir Haj-Dahmane, PhD. Endocannabinoids are naturally produced chemical compounds in the brain that affect motor control, cognition, emotions and behavior. As the name suggests, they are similar to the chemicals found in marijuana (Cannabis sativa) and its active ingredient, delta-9-tetrahydrocannabinol (THC). “Chronic stress is one of the major causes of depression,” Haj-Dahmane says. “Using compounds derived from cannabis, marijuana, to restore normal endocannabinoid function could potentially help stabilize moods and ease depression.” He cautions this is preliminary research. “Our research thus far has used animal models; there is still a long way to go before we know whether this can be effective in humans,” he says. “However, we have seen that some people who suffer from post-traumatic stress disorder have reported relief using marijuana.” Haj-Dahmane says the next step in the research is to see if using a marijuana extract, cannabidiol (CBD), restores normal behaviors in the animals without leading to dependence on the drug. The study, co-authored by Roh-Yu Shen, PhD, RIA senior research scientist, was funded by a grant from the National Institute of Mental Health. It appeared in the fall issue of the Journal of Neuroscience.

Person experiencing chronic stress


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The Maestro System

EnteroMedic’s Maestro system

The Maestro® System comprises of a subcutaneously embedded rechargeable neuroregulator and two cathodes that are laparoscopically embedded by a bariatric specialist. It conveys Vbloc® vagal blocking treatment through these cathodes that are set in contact with the trunks of the vagus nerves just over the intersection between the throat and the stomach. The gadget discontinuously squares vagal nerve motions all through the persistent’s waking hours. The Maestro System is energized utilizing an outside versatile charger and transmit curl worn by the patient. The gadget can be non-intrusively customized, and it can be balanced, deactivated, reactivated or totally uprooted if crave. EnteroMedics® has significant experience with VBLOC Therapy; more than 600 patients have been implanted with the Maestro System to date, some out to five years. Data on safety, efficacy and sustained weight loss with VBLOC Therapy is being collected in multiple clinical trials.  The major components of the Maestro System include: Neuroregulator. The neuroregulator, sometimes referred to as a neuroblocking pulse generator, is an implanted device that controls the delivery of VBLOC Therapy to the vagus nerve. It is surgically implanted just below, and parallel to, the skin, typically on the side of the body over the ribs. Lead System. Proprietary leads are powered by the neuroregulator and deliver electrical pulses to the vagus nerve via the electrodes. The leads and electrodes are similar to those used in traditional cardiac rhythm management products. Mobile Charger. The Mobile Charger is an electronic device worn by the patient externally while recharging the device. It connects to the transmit coil and provides information on the battery status of the neuroregulator and the Mobile Charger. Transmit Coil. The Transmit Coil is positioned for short periods of time over the implanted neuroregulator to deliver radio frequency battery charging and therapy programming information across the skin into the device.

Image by EnteroMedic’s Maestro system

Printed Tattoo Glucose Sensor

Temporary tattoo

Diabetes is one of the most widely spread modern lifestyle diseases affecting hundreds of millions of people and is among the leading causes of deaths globally. Frequent monitoring of glucose is essential for optimal management of the disease and avoiding its associated problems. Extensive research has led to the introduction and widespread use of self-testing blood glucose meters. However, such self-testing methods rely on inconvenient and painful blood sampling from the finger tip that compromises the patient’s compliance. Efforts aimed at addressing this drawback have resulted in several commercial continuous glucose monitoring systems. These enzyme-based microneedle sensors are inserted under the skin to measure glucose levels in the skin interstitial fluid or ISF fluid. Such minimally invasive sensing methods are based on the correlation between glucose levels in the ISF and in blood. Completely noninvasive glucose sensing systems are highly desired to address the limitations of these subcutaneous systems and are thus ideal for diabetes management. Extensive efforts have thus been aimed at developing noninvasive glucose sensors that rely on optical, spectroscopic, ultrasound, heat, electrical, or electrochemical techniques. Among these, electrochemical techniques have shown the greatest promise. Cygnus Inc. introduced the GlucoWatch electrochemical glucose sensor for noninvasive glucose monitoring. This platform relied on the reverse iontophoresis technique to extract ISF glucose to the surface of the skin followed by the detection via an enzymatic electrochemical glucose sensor. Reverse ionotophoresis involves applying a mild current to the epidermis causing ions to migrate across the skin and toward the electrodes. Sodium ions are the major charge carriers due to the negative charge of the human skin at neutral pH.

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Preservation of Breast Biopsy Specimens

Dr. Pat Whitworth

In place Medical Corporation won FDA 510(k) leeway for its Intact extraction framework to be utilized to safeguard evacuated breast tissue of up to 30mm in breadth. Once the territory is arranged, the wand is embedded through a 6mm-8mm cut and the tip grows to encompass the tissue. A 10 second blast of radiofrequency vitality is conveyed through the tip removing the tissue around the example and liberating it for simple evacuation. The specimen keeps up its building design and is prepared for standard histologic assessment. The gadget accompanies four distinctive bushel sizes that wrap around the example, while the same wand is utilized with every one of the four. Dr. Pat Whitworth, Director, Nashville Breast Center, noted, “This new FDA clearance is highly significant, not just for Intact Medical, but more importantly, for women’s health professionals and patients, globally.  The expanded clearance recognizes the unique features and significant advantages of the Intact technology compared to core needle biopsy and open surgical excision procedures in certain situations. Specifically, for small breast lesions up to 30mm in diameter, the ability of the Intact system to remove and preserve the entire lesion architecture for assessment by the pathologist combines the minimally-invasive benefits of core biopsy with the diagnostic assurances of traditional surgical excisional biopsy. As someone who has performed more than 1,000 procedures with the Intact, I can attest to the advantages of this option for my patients.” John Vacha, President and Chief Executive Officer of Intact Medical, noted, “This FDA clearance represents an important milestone for the company and is an acknowledgement of the unique capabilities of the Intact technology.

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Lab-Grown Vagina

Tube in lab

Lab-grown fully functional vaginas

Following the time when researchers developed a human bladder in a lab in 1996, analysts have kept on developing more unpredictable organs. Beating human hearts have additionally been become in the lab and infected with ailment to test different medications.As a result of these medical advancements, people have had their lives changed for the better. One of the most recent successful lab grown organ transplants is the female vagina. Researchers were able to successfully implant lab-grown vaginas into 4 teenage girls, and the results were published earlier this year. Tissue samples from the poorly developed vulva as well as a biodegradable scaffold were used.  a“We were able to shape the scaffold specifically for each patient, and place this device with the cells in a bio-reactor – which is an oven-like device and has the same conditions as the human body – for about a week, until it was slightly more mature.”– Dr. Anthony Atala, lead researcher, director of Wake Forest Baptist Medical Centre’s Institute for regenerative medicine. They grew each vagina from the cells of each patient and then implanted them. So far so good, as the patients are now able to be sexually active and have reported normal functioning. All of the women reported normal  levels of “desire, arousal, lubrication, orgasm and satisfaction.”

Dr. Anthony Atala

The vaginas were constructed at the Wake Forest Baptist Medical Centre in North Carolina. Dr. Anthony Atala said that  it is really for the first time we’ve created a whole organ that was never there to start with, it was a challenge. A functioning vagina was a very important thing for these women’s lives and witnessing the difference it made to them was very rewarding to see.” So for those women, even you are Asian teacher, manager, assistant, US comfort women, Indian nurses, or whatever race you are and job you have, and having problem with your vagina, you might want to consider this new medical breakthrough.

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3D Printing of Replica Organs For Radiotherapy

Liver Replica

Analysts have utilized 3d printing to deliver reproduction models of tumors and organs of patients with cancer, to help ascertain correctly the amount of radiation has been conveyed to the cancer. Preliminary studies show the models can accurately replicate the shape of a patient’s tumor and the surrounding organs and could mimic the exact position of the tumor within the patient’s body. Initial tests at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust found the models allowed the dose of radiation a patient has received to be calculated more accurately, allowing subsequent doses to be adjusted accordingly. Researchers were aiming to improve molecular radiotherapy – in which doctors give a patient a radioactive drug designed to target a tumor, and aim for a dose high enough to kill cancer cells but not so high that it damages healthy tissue. The work was funded by the NIHR Biomedical Research Centre at The Royal Marsden and The Institute of Cancer Research (ICR), with additional support from the ICR’s PhD programme. The replica tumors and organs  known as ‘phantoms’  were filled with the same radioactive liquid administered to patients and monitored to mimic the likely effects of radiotherapy in that individual patient. The phantoms ­made from a type of plastic and printed by researchers from the Joint Department of Physics at the ICR and The Royal Marsden are based on scans taken during patient treatment. The researchers originally produced hand-made individual models of a tumor before turning to 3D printing technology. The researchers, who are physicists, work in molecular radiotherapy, a treatment that is used for thyroid cancer, adult neuroendocrine tumors, childhood neuroblastoma and bone metastases from prostate cancer.

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